ITGA2B - integrin subunit alpha 2b Gene

Also Known as GT; GT1; GTA; CD41; GP2B; HPA3; CD41B; GPIIb; BDPLT2; BDPLT16; PPP1R93

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3674

About ITGA2B

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:44,372,181-44,389,649 (from NCBI)

This gene has 10 transcripts (splice variants), 190 orthologues, 17 paralogues and is associated with 5 phenotypes. Biased expression in bone marrow (RPKM 6.2), testis (RPKM 1.4) and 8 other tissues.

Summary

This gene encodes a member of the Integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 Integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia. [provided by RefSeq, Jan 2016]

ITGA2B Products (1)

mRNA	Protein	Name
NM_000419.5	NP_000410.2	integrin alpha-IIb preproprotein

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	11606749	GOA
enables molecular adaptor activity	EXP EXP: Inferred from Experiment	11412103	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14681217	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular exosome	IDA IDA: Inferred from direct assay	15908444	GOA
part of integrin alphaIIb-beta3 complex	IPI IPI: Inferred from physical interaction	15378069	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITGA2B Protein Structure

FG-GAP

Integrin_alpha2

Integrin_alpha

0
200
400
600
800
1039 a.a.

Protein Preferred Names	Protein Names
integrin alpha-IIb	GPalpha IIb

ITGA2B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ITGA2B	P08514	ITGA2B	Homo sapiens	P08514	Solution Sedimentation	11606749
Intra	ITGA2B	P08514	ITGA2B	Homo sapiens	P08514	Comig Non-Denat Gel	11606749
Intra	ITGA2B	P08514	ITGA2B	Homo sapiens	P08514	ToxCat	15067009
Intra	ITGA2B	P08514	ITGA2B	Homo sapiens	P08514	Solution Sedimentation	15067009
Intra	ITGA2B	P08514	ITGB3	Homo sapiens	P05106	TAP	19279667
Intra	ITGA2B	P08514	ITGA2B	Homo sapiens	P08514	Comig Non-Denat Gel	15067009
Intra	ITGA2B	P08514	ITGB3	Homo sapiens	P05106	ELISA	30305279
Intra	ITGA2B	P08514	ITGB3	Homo sapiens	P05106	X-Ray Diffraction	15378069
Intra	ITGA2B	P08514	ITGA2B	Homo sapiens	P08514	Lex-A Dimerization	14681217
Intra	ITGA2B	P08514	ITGB3	Homo sapiens	P05106	NMR	19279667
Intra	ITGA2B	P08514	VWF	Homo sapiens	P04275	ELISA	30305279

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ITGA2B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77716	Integrin alpha 2B beta 3 Protein, Human (HEK293, His)	P08514 (L32-R993)&P05106 (G27-D718)	≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.

ITGA2B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80058	CD41 Antibody (YA535)	WB, IHC-P	Human
HY-P82094	CD41 Antibody (YA1839)	WB, IHC-P	Human, Mouse, Rat
HY-P84009	CD41 Antibody (YA3706)	IHC-P, FC, ELISA	Human
HY-P84009A	CD41 Antibody (YA3706)(PBS only)	IHC-P, FC, ELISA	Human
HY-P85675	CD41 Antibody (YA5367)	IHC-P, ICC/IF	Human
HY-P86724	CD41 Antibody (YA6416)	WB, FC	Human
HY-P86724A	CD41 Antibody (YA6416)(PBS only)	WB, FC	Human

Related Diseases

Diseases	Alias
Glanzmann Thrombasthenia 1	Glanzmann Thrombasthenia Thrombasthenia Of Glanzmann And Naegeli Glanzmann'S Thrombasthenia Bdplt2 Platelet Glycoprotein Iib-Iiia Deficiency Deficiency Of Platelet Fibrinogen Receptor GT1 Gt Platelet Fibrinogen Receptor Deficiency Glycoprotein Complex Iib-Iiia Deficiency Deficiency Of Glycoprotein Complex Iib-Iiia Glycoprotein Iib/Iiia Defect Glanzmann Thrombasthenia, Type A Thrombasthenia Bleeding Disorder, Platelet-Type, 2 Gp Iib-Iiia Complex Deficiency Deficiency Of Gp Iib-Iiia Complex Platelet-Type Bleeding Disorder 2 Thrombocytasthenia Deficiency Of Gp 2b 3a Complex Diacyclothrombopathia 2b 3a Glanzmann Thrombasthenia Type A Platelet Fibrinogen Receptor, Deficiency Of Platelet Glycoprotein 2b 3a Deficiency Glanzmann Disease Glanzmann-Naegeli Disorder Hereditary Hemorrhagic Thrombasthenia Hereditary Thrombasthenia Bleeding Disorder Platelet-Type 2
Bleeding Disorder, Platelet-Type, 16	Platelet-Type Bleeding Disorder 16 BDPLT16 Glanzmann Thrombasthenia-Like With Macrothrombocytopenia 1 Bleeding Disorder, Platelet-Type, 16, Autosomal Dominant Autosomal Dominant Glanzmann Thrombasthenia Autosomal Dominant Thrombasthenia Of Glanzmann And Naegeli Bleeding Disorder, Platelet Type 16 Glanzmann Thrombasthenia, Autosomal Dominant
Thrombasthenia
Autosomal Dominant Macrothrombocytopenia
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Erythroleukemia
Fetal And Neonatal Alloimmune Thrombocytopenia	Nait Neonatal Alloimmune Thrombocytopenia Fnait
Bernard-Soulier Syndrome	Giant Platelet Syndrome BSS Von Willebrand Factor Receptor Deficiency Bdplt1 Platelet Glycoprotein Ib Deficiency Bernard-Soulier Syndrome, Type A1 Bernard-Soulier Syndrome, Type B Bernard Soulier Syndrome Deficiency Of Platelet Glycoprotein 1b Hemorrhagiparous Thrombocytic Dystrophy Bernard-Soulier Syndrome Type C Bleeding Disorder, Platelet-Type, 1 Glycoprotein Ib, Platelet, Deficiency Of Giant Platelet Disorder, Isolated Giant Platelet Disease Macrothrombocytopenia, Familial Bernard-Soulier Type Bernard-Soulier Syndrome, Type C Bernard - Soulier Thrombopathy Hemorrhagic Dystrophic Thrombocytopenia Thrombopathy, Bernard-Soulier Platelet Glycoprotein 1b, Deficiency Of Hemorrhagioparous Thrombocytic Dystrophy Bernard-Soulier Syndrome Type A1 Bernard-Soulier Syndrome Type B Bleeding Disorder Platelet-Type 1 Gpd Macrothrombocytopenia, Familial, Bernard-Soulier Type
Heparin-Induced Thrombocytopenia	Hit Hat Heparin-Associated Thrombocytopenia Heparin-Induced Thrombocytopenia Type 2
Thrombocytopenia Due To Platelet Alloimmunization	Immune Thrombocytopenia Autoimmune Thrombocytopenia Immune Thrombocytopenic Purpura Itp Auto-Immune Thrombocytopenia Thrombocytopenia Due To Immune Destruction Autoimmune Thrombocytopenic Purpura Idiopathic Thrombocytopenic Purpura Werlhof Disease
Blood Platelet Disease	Platelet Disorder Blood Platelet Disorders Thrombocytopathy Platelet Dysfunction Platelet Disorders Qualitative Platelet Deficiency
Purpura	Purpuric Disorder
Primary Thrombocytopenia
Aspirin Allergy	Acetylsalicylic Acid Allergy Asa Allergy
Lateral Myocardial Infarction
Von Willebrand'S Disease	Von Willebrand Disease Von Willebrand Disorder Vascular Pseudohemophilia Hereditary Von Willebrand Disease Vwd Vascular Hemophilia Von Willebrand'S-Jurgens' Disease Von Willebrand-Jrgens Disease Von Willebrand Factor Deficiency Von Willebrand Factor, Deficiency Angiohemophilia Von Willebrand'S Factor Deficiency Von Willebrand Diseases Factor Viii Deficiency With Vascular Defect Vascular Haemophilia Willebrand Jurgen Thrombopathy Pseudohaemophilia Minot-Von Willebrand-Jurgen Disease Angiohaemophilia Angiohaemophilia A Angiohaemophilia B
Myeloproliferative Syndrome, Transient	Transient Abnormal Myelopoiesis Transient Myeloproliferative Syndrome Transient Myeloproliferative Disease Mst Tam Leukemia, Transient, Of Down Syndrome Tmd Leukemia, Transient Transient Leukemia Transient Leukemia Of Down Syndrome
Thrombosis	Thrombosis Of Blood Vessel
Acute Myocardial Infarction	Cardiac Attack Heart Attack
Intermediate Coronary Syndrome	Unstable Angina Angina At Rest Anginal Chest Pain At Rest Impending Infarction Preinfarction Angina Worsening Angina Angina, Unstable Myocardial Preinfarction Syndrome Angina Unstable Crescendo Angina Angina Decubitus Acute Coronary Insufficiency Unstable Angina Pectoris Preinfarctional Angina Pectoris Worsening Effort Angina Preinfarction Syndrome Unstable Angina Pectoris Syndrome Unstable Anginal Attack Unstable Cardiac Angina Unstable Chest Angina Unstable Heart Angina De Novo Effort Angina Pectoris Crescendo Angina Pectoris Ua - [Unstable Angina]
Autoimmune Disease Of Blood
Blood Coagulation Disease	Blood Coagulation Disorders Coagulation Protein Disease Inherited Blood Coagulation Disease Postpartum Coagulation Defect Postpartum Coagulation Defect With Delivery Coagulation Protein Disorders Puerperal Coagulopathy
Carotid Artery Thrombosis
Basilar Artery Occlusion
Bleeding Disorder, Platelet-Type, 18	Platelet-Type Bleeding Disorder 18 BDPLT18 Bleeding Disorder Due To Calcium- And Dag-Regulated Guanine Exchange Factor-1 Deficiency Bleeding Disorder Due To Caldag-Gefi Deficiency Bleeding Disorder, Platelet Type 18
Qualitative Platelet Defect	Qualitative Platelet Defects Qualitative Platelet Deficiency Thrombocytopathy Platelet Defect Platelet Disorder Thrombopathy Platelet Granule Defect Thrombocytasthenia Thromboasthenia Dystrophic Thrombocytopathy Haemorrhagic Thrombasthenia Granulopenic Thrombocytopathy
Bleeding Disorder, Platelet-Type, 11	BDPLT11 Glycoprotein Vi Deficiency Gp Vi Deficiency Platelet-Type Bleeding Disorder 11 Bleeding Diathesis Due To A Collagen Receptor Defect Bleeding Diathesis Due To Glycoprotein Vi Deficiency Platelet-Type Bleeding Disorder-11 Bleeding Disorder, Platelet Type 11 Hemorrhage
Thrombocytopenic Purpura, Autoimmune	Idiopathic Thrombocytopenic Purpura Autoimmune Thrombocytopenic Purpura Immune Thrombocytopenic Purpura Itp Idiopathic Purpura AITP Ideopath Thrombocytopenic Pur Primary Thrombocytopenic Purpura Werlhof'S Disease Thrombocytopenic Purpura Autoimmune Purpura Thrombocytopenic Idiopathic Purpura, Thrombocytopenic, Idiopathic Autoimmune Thrombocytopenia Thrombocytopenia Due To Platelet Alloimmunization Idiopathic Thrombocytopenia Idiopathic Thrombocytopenia Purpura Frank'S Essential Thrombocytopenia Itp - [Idiopathic Thrombocytopenia Purpura] Werlhof Disease Primary Autoimmune Thrombocytopenic Purpura Haemorrhagic Purpura Essential Thrombocytopenia Purpura Haemorrhagica
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Acquired Thrombocytopenia	Secondary Thrombocytopenia
Coronary Thrombosis	Coronary Artery Thrombosis
Arteriosclerosis	Arteriosclerotic Vascular Disease
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Anomaly Coronary Artery Disease, Susceptibility To Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries
Gastric Teratoma	Teratoma Of Stomach
Intracranial Thrombosis	Cerebral Thrombosis Thrombosis Of Cerebral Veins Cerebral Arterial Thrombosis
Childhood Acute Megakaryoblastic Leukemia	Pediatric Non-Down Syndrome Acute Megakaryoblastic Leukemia
Myelitis	Spinal Cord Inflammation Nos Radiculomyelitis Nos Myeloradiculitis
Splenic Sequestration
Hemoglobin H Disease	HBH Hemoglobin H Disease, Nondeletional Hemoglobin H Disease, Deletional Alpha-Thalassemia Intermedia Haemoglobin H Disease Alpha-Thalassemia, Hemoglobin H Type Hemoglobin H Disease, Deletional And Nondeletional Alpha Thalassemia, Haemoglobin H Type Alpha Thalassemia, Hemoglobin H Type Haemoglobin H Disease, Deletional Hbh Disease Alpha-Thalassemia Hemoglobin H Type Hemoglobin H Disease Deletional Hemoglobin H Disease Non-Deletional Alpha-Thalassemia Alpha - /- - Or Mutational Forms Of Alpha-Thalassaemia Alpha Thalassaemia Intermedia
Malignant Gastric Germ Cell Tumor	Germ Cell Tumor Of The Stomach Germ Cell Tumour Of The Stomach Malignant Gastric Germ Cell Tumour
Amegakaryocytic Thrombocytopenia, Congenital	Congenital Amegakaryocytic Thrombocytopenia CAMT Thrombocytopenia, Congenital Amegakaryocytic Congenital Amegakaryocytic Thrombocytopenic Purpura Thrombocytopenia Congenital Amegakaryocytic Thrombocytopenia, Amegakaryocytic, Congenital
Gray Platelet Syndrome	Platelet Alpha-Granule Deficiency GPS Bdplt4 Bleeding Disorder, Platelet-Type, 4 Grey Platelet Syndrome Platelet-Type Bleeding Disorder 4 Marked Decrease Or Absence Of Alpha-Granules And Of Platelet-Specific Alpha-Granule Proteins Deficient Alpha Granule Syndrome Platelet Alpha Granule Deficiency Platelet Granule Defect Alpha Storage Pool Deficiency Bleeding Disorder Platelet-Type 4
Hemorrhagic Disease	Hemorrhagic Disorders Hemorrhagic Diathesis Hemorrhagic Diseases Bleeding Tendency Acquired Coagulation Factor Inhibitor Disorder Acquired Inhibitor Of Coagulation Antithrombinaemia Antithromboplastinogenaemia Circulating Anticoagulant Disorder Haemorrhagic Disorder Due To Antithrombinaemia Haemorrhagic Disorder Due To Excess Administered Heparin Antithromboplastinaemia Haemorrhagic Disorder Due To Hyperheparinemia
Scott Syndrome	SCTS Bdplt7 Prothrombin Consumption Deficiency Bleeding Abnormality Due To Deficiency Of Platelet Binding Of Factor X Bleeding Disorder, Platelet-Type, 7 Prothrombin Conversion Defect, Familial Prothrombin Consumption Inhibitor, Familial Bleeding Abnormality Due To Deficiency Of Platelet Biding Of Factor X Familial Prothrombin Consumption Inhibitor Familial Prothrombin Conversion Defect Platelet-Type Bleeding Disorder 7 Platelet Factor X Receptor Deficiency Bleeding Disorder Platelet-Type 7 Prothrombin Consumption Inhibitor Familial Prothrombin Conversion Defect Familial
Acute Erythroid Leukemia	Acute Erythroleukemia Di Guglielmo'S Syndrome Aml M6 Acute Myeloid Leukemia Fab-M6 Acute Myeloid Leukemia M6 Erythroleukemia Aml-M6 Acute Erythroleukemia M6a Subtype Acute Erythroleukemia M6b Subtype Di Guglielmo Syndrome Acute Myeloid Leukemia, M6 Type Acute Erythroblastic Leukemia Acute Erythroleukemia - M6a Subtype Acute Erythroleukemia - M6b Subtype Acute Erythraemia And Erythroleukaemia Acute Erythroid Leukaemia Without Mention Of Remission Erythraemia Erythraemic Myelosis Erythroleukaemia Acute Erythraemic Myelosis Acute Erythraemia
Carotid Artery Disease	Carotid Artery Diseases Disorder Of Carotid Artery
Infective Endocarditis	Bacterial Endocarditis Endocarditis, Infective Infectious Endocarditis Endocarditis Infective
Occlusion Precerebral Artery	Occlusion And Stenosis Of Multiple And Bilateral Precerebral Arteries Occlusion And Stenosis Of Precerebral Artery
Acute Megakaryocytic Leukemia	Acute Megakaryoblastic Leukemia Acute Megakaryoblastic Leukaemia Megakaryocytic Myelosis Thrombocytic Leukaemia Amkl Aml M7 Acute Myeloblastic Leukemia Type 7 Acute Myeloid Leukemia M7 Megakaryoblastic Leukemia Acute Leukemia, Megakaryoblastic, Acute Acute Myeloid Leukaemia, M7 Acute Megakaryocytic Leukaemia Acute Megakaryoblastic Leukaemia, Fab M7 Fab M7 Malignant Megakaryocytosis M7 - Acute Megakaryoblastic Leukaemia Megakaryoblastic Leukaemia Megakaryocytic Leukaemia Acute Megakaryoblastic Leukaemia, Nos Acute Megakaryoblastic Leukaemia Without Mention Of Remission
Intracranial Embolism	Cerebral Embolism Cerebral Embolism With Cerebral Infarction
Beta-Thalassemia Major	Cooley'S Anemia Cooley Anemia Mediterranean Anemia
Afibrinogenemia, Congenital	Congenital Afibrinogenemia Afibrinogenemia Factor I Deficiency Familial Afibrinogenemia Hypofibrinogenemia, Congenital Fibrinogen Deficiency Afibrinogenemia Congenital CAFBN Congenital Hypofibrinogenemia Hypofibrinogenemia Complement Factor I Deficiency
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Acute Anterolateral Myocardial Infarction	Acute Myocardial Infarction Of Anterolateral Wall
Fetal Hemoglobin Quantitative Trait Locus 1	Hereditary Persistence Of Fetal Hemoglobin Delta-Beta-Thalassemia Delta-Beta Thalassemia Delta Beta-Thalassemia HBFQTL1 Hemoglobin F, Hereditary Persistence Of Hpfh Hereditary Persistence Of Fetal Hemoglobin, Hb Gene Cluster-Related Hemoglobin, Fetal, Quantitative Trait Locus 1 Hereditary Persistence Of Fetal Hemoglobin Thalassemia Hpfh - [Hereditary Persistence Of Fetal Haemoglobin] Fetal Haemoglobin Persistence Of Fetal Haemoglobin Persistent Haemoglobin F
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Alpha-Thalassemia	Alpha Thalassemia Alpha Thalassaemia Alpha Plus Thalassemia Thalassemia, Alpha- Thalassemias, Alpha- A-Thalassemia Α-Thalassemia A-THAL Thalassemia Alpha Thalassaemia Syndrome
Arrhythmogenic Right Ventricular Cardiomyopathy	Arrhythmogenic Right Ventricular Dysplasia Arvc Arvd Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Arvc Cardiomyopathy Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia Arvd/C Right Ventricular Dysplasia, Arrhythmogenic Ventricular Dysplasia, Right, Arrhythmogenic Cardiomyopathy, Ventricular, Right, Arrhythmogenic Dysplasia, Arrhythmogenic Right Ventricular
Essential Thrombocythemia	Essential Thrombocytosis Familial Thrombocytosis Hemorrhagic Thrombocythemia Hereditary Thrombocythemia Primary Thrombocytosis Idiopathic Thrombocythemia Primary Thrombocythemia Thrombocythemia, Essential Essential Thrombocythaemia Et Familial Thrombocythemia Thrombocythemia Essential
Diabetes Mellitus	Diabetes
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06949	ITGA2B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19782	Itga2b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26279	Itga2b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ITGA2B	RGD	RGD:1596428
Mus musculus	ITGA2B	MGD	MGI:96601
Macaca mulatta	ITGA2B	VGNC	VGNC:73776
Bos taurus	ITGA2B	VGNC	VGNC:30314
Canis familiaris	ITGA2B	VGNC	VGNC:42124
Felis catus	ITGA2B	VGNC	VGNC:67840
Others	ITGA2B	NCBI